Bilirubin waa xabbad xabbad, kaas oo ah badeecada hadhaaga ah ee ka yimaada unugyada dhiigga cas cas ee burburay. Caadi ahaan, qof weyn oo caafimaad qaba oo ku jira plasma dhiiggu wuxuu ka kooban yahay qadar yar oo walaxdan ah (3,4 - 22,2 μmol / l), iyo sidoo kale qadar gaar ah oo kaadida ah qaabka urobilinogens (4 mg) maalin kasta.
Qiyaastii 96% ka mid ah bilirubin oo ku jira dhiigga waa bilirubin aan toos ahayn oo aan la xalin, kaas oo ah wax lagu xalliyo biyaha waana sun, sababtoo ah wuxuu awoodaa in uu si fudud u galo xuubka unugyada iyo carqaladeeyo shaqooyinka muhiimka ah ee unugyada. Qeybta 4% ee soo hadhay waa bilirubin toos ah, biyaha lagu dhalaalayo, gooyo kelyaha iyo kaadida kaadida. Bilirubin guud waa heerka guud ee bilirubin toos ah iyo aan tooska ahayn.
Xanuunada qaarkood, maadada bilirubin ee ku jirta dhiigga, iyo kaadida kaadida, ayaa sii kordheysa. Tani waxay keentaa cagaarshowga iyo madadaalinta kaadida.
Sababaha keena heerarka bilirubin ee dadka waaweyn
Bal aan ka fekerno, maxaa sababaha loo yaqaan 'bilirubin' ee guud ahaan ama midka caadiga ah ee qofku ku kicin karo ama kor u qaadi karo.
Sababaha loo yaqaan bilirubin toos ah
Heerka bileerka ee tooska ah ee dhiigga ayaa kor u kacay sababtoo ah xad-gudub ka soo baxa xitaa. Sidaas darteed, xitaa waxaa loo diraa dhiiga, maaha caloosha. Sababta arrintani waa inta badan hababka soo socda:
- cagaarshowga viral etiology ee qaabka ugu ba'an (cagaarshowga A, B, oo leh cudurka mononucleosis);
- cagaarshow ee cudurada bakteeriyada (leptospirosis, brucellosis);
- cagaarshow joogtada ah;
- Cagaarshowga nooca automat;
- cagaarshow nooca cagaarsho (oo ay sabab u tahay daaweynta hoormoonka, daawooyinka aan anti-inflammatory ahayn ee ka hortagga ah, daawooyinka antitumor iyo daawooyinka ka hortagga qaaxada);
- Cagaarshowga sunta (sunta leh sunta fungal, sunta sunta kiimikada);
- kansarka sanbabada, beerka ama beeryarada;
- cholelithiasis;
- cirrhosis biliary ah;
- cudurrada Rotor, Dabin-Johnson.
Sababaha loo yaqaan bilirubin aan toos ahayn
Kordhinta nuxurta bilirubin aan toos ahayn ayaa lala xiriirin karaa burburka degdega ah ee unugyada dhiigga cas ama ayadoo carqaladeyneysa habka loo yaqaan bilirubin aan toos ahayn. Waxaa muhiim ah in la ogaado tan, tan iyo bilirubin aan toos ahayn oo biyo ah ma baabi'iyo, xitaa iyada oo korodhka weyn ee heerarka dhiigga ah, ma jiraan wax xayiraad ah ee falanqaynta kaadida. Sidaa darteed, sababaha tani waxay noqon kartaa:
- Dhiig karka uur-ku-jirka ah (sickle cell, spherocytic, nesferocytic, thallasemia, cudur Marciyafawa-Michele);
- Dhiig karka uumi-yari ah (ka hortaga rheumatoid arthritis, lupus erythematosus, lymphocytic leukemia, lymphanganulmatosis, iwm);
- Daawada insulin, asbirin, levomycetin, levofloxacin, cephalosporins, iwm.);
- cudurrada Lucy-Driskol, Gilbert, Kriegler-Nayyar;
- cudurada faafa (duumada, tafatirka, sepsis);
- xummad dhiig ah oo asmada ah ( sumaynaya boqoshaada sunta leh, sunta, qaniinyada cayayaanka, masaska, sumeynaya boqoshaada, macdanta, cusbada bakteeriyada, iwm.).
Sababta keentay bilirubin koritaanka uurka
Bilirubin kordhay ayaa inta badan lagu arkaa haweenka uurka leh (cagaarshowga xilliga uurka). Sababaha tani waxay u qaybsan yihiin laba kooxood:
- sababtoo ah cudur-sidaha uurka (xanaaqa ba'an ee beerka, gestosis, matag xad-dhaaf ah, iwm);
- oo ay sababaan cuduro kala duwan oo kala duwan (cagaarshow, hemolytic anemia, iwm).
Sababaha keena kaadida oo kor u kaca
Heerarka kordhaysa ee kaadida ku jirta kaadida ayaa lagu arkay cirbado ay weheliyaan waxyeelo u gaarta unugyada beerka
- Cagaarshow;
- cirrhosis of beerka ;
- dhaawaca beerka ee qiiqa;
- dhaawaca beerka, iwm.
Daaweynta bileerubin sare leh
Haddii baaritaanku muujiyo in bilirubin ee dhiigga ama kaadida ay sare u kacday, mabaadiida daaweynta waxay ku xirnaan doontaa sababaha cudurkan. Caadi ahaan, qaababka daaweynta waxaa ka mid ah qaadashada daawooyinka iyo hagaajinta cuntada.