Antibodies to thyroglobulin - waa tan ugu muhiimsan ee lagu ogaanayo cudurada tayroodhka ee autoimmune, sida cudurka thyroiditis atrophic autoimmune, cudurka Hashimoto, xajmiga goosiga sunta, iwm.
Waa maxay thyroglobulin?
Dhab ahaantii, thyroglobulin waa glycoprotein, oo ah qayb ka mid ah kolloidaha qanjidhada ee qanjirka thyroid. Waxay fulisaa hawsha loo yaqaan 'propeptide' ee qaabka loo yaqaan 'hormoonada' thyroid. Ereyada fudud, thyroglobulin waxaa lagu tilmaami karaa borotiinka oo ku yaala gudaha qanjidhada qanjirka thyroid. Xilliga qarsoon ee hoormoonka thyroglobulin qadar yar ayaa ku dhacaya dhiigga. Sida laga soo xigtay qaar ka mid ah daawooyinka aan la garanayn, sababaha, waxay noqon karaan kuwo asaas ah, kaas oo jidhku bilaabo inuu soo saaro unugyo. Antibodies, oo lala xiriiriyo qaboojiyeyaasha thyroglobulin, waxay bilaabaan inay la jaanqaadaan ficilka hoormoonka. Xaaladdan, qanjidhada thyroid waxay bilaabmaysaa inay jidhka siiso tiro hormoon ah oo tiro badan, khalkhal geliso dheef-shiid kiimikaad iyo shaqada wadnaha.
Antibodies for thyroglobulin waxaa lagu go'aamiyaa ujeedada ogaanshaha cudurka cudurada tayroodh. Sidaa darteed, sida ay u xakameyn karaan thyroglobulin, iyadoo carqaladeeya suunka caadiga ah ee hoormoonka tayroodh. Marka unugyada difaaca jirka ee tiroklobulin la kordhiyo, waxay keeni kartaa caabuqa qanjidhada thyroid, hypothyroidism ama, liddi ahaan, si xad dhaaf ah u kiciyaan qanjirada waxayna sababtaa foosha ( hyperthyroidism ).
Antibodies to thyroglobulin - caadada
Noocyada difaaca jirka ee thyroglobulin waa qiimo kasta oo U / ml ah inta u dhaxaysa 0 ilaa 18. Sidaa darteed, waxaa lagu soo gabagabeyn karaa in unugyada difaaca jirka ee tirokoobinta aan la yarayn.
Antibodies to thyroglobulin oo ka sarreysa heerka caadiga ah waxaa laga heli karaa dadka qaba cillad caafimaad leh. Xaaladdan oo kale, ragga ragga ah ee difaaca jirka ee thyroglobulin ayaa si aad ah u kordhay marka loo eego haweenka, gaar ahaan dumarka da 'da' weyn.
Sidee loo go'aamiyaa qiyaasta difaaca jirka ee thyroglobulin?
Qadarka difaaca jirka ee thyroglobulin ee jidhka waxaa lagu aasaasay iyadoo la falanqeynayo dhiigga ka soo baxa ulnar. Falanqayntan waxaa loo qoondeeyey koox dad ah, sida:
- bukaanka qaba hypothyroidism (subclinical ama muuqaal ah) si loo ogaado sababta keentay muuqaalka;
- si loo go'aamiyo sababta kor u kaca ee qiyaasta qanjirka thyroid;
- bukaanada qaata daawada interferon iyo lithium, amiodarone. Bukaan-socodka kuwaas oo difaaca jirka ee tireoglobulin ayaa la kordhiyaa, iyadoo asalka u ah qaadashada daawooyinkan sidoo kale ay ku dhici karto cudurka tayroodh;
- Fadlan, haddii hooyadu leedahay antibodies to thyroglobulin oo ka sareysa heerka caadiga ah.
Sababo la xiriira falanqaynta difaaca jirka ee thyroglobulin waxaa suurtagal ah in la qiimeeyo shaqooyinka qanjidhada thyroid, si loo dhiso dabeecadda cudurkiisa iyo heerka qiyaasta neefsiga, si loo muujiyo cudurrada dhaxalka ah.
Antibodies for thyroglobulin ayaa ka sarreeya caadi ahaan
Haddii difaaca jirka ee tayroglobulin la kordhiyo, sababaha ayaa noqon kara jiritaanka cudurada soo socda:
- subacute ama thyroiditis (40-70% bukaanada), Hashimoto's thyroiditis (97% bukaanada);
- Cudurka Graves '(51% bukaanada);
- idiopathic myxedema (95% bukaanada);
- hypothyroidism (70% bukaanada);
- gogol-xumada suntan (40% bukaanada);
- daaweynta tayroodhka tayroodhka ah ee loo yaqaan 'thyroid follicular' iyo papillary carcinomas (nonmedullary carcinomas (15-30% bukaanada);
- cuduro kale oo bani'aadamnimo, oo ay ku jiraan dhiig-yaraanta dhiig-yaraanta.
Waxaa intaa dheer, haddii difaaca jirka ee thyroglobulin uu xoogaa kor u kaco, tani waxay muujin kartaa joogitaanka cilladaha koromosoomka, gaar ahaan, Down syndrome ama Turner syndrome.
Suurtagalnimada in la yareeyo heerka unugyada difaaca jirka ilaa thyroglobulin ee jidhka adigoo qaadanaya daawooyinka waa mid aad u hooseeya. Daawada casriga ah, haddii difaaca jirka ee tireoglobulin la kordhiyo, daaweynta, si loo keeno heerkooda heerkulka jidhka ee aan caadiga ahayn. Sidaa darteed, isticmaalka xiidmaha, plasmapheresis, corticosteroids, "immunomodulators" waa wax aan faa'iido lahayn, xittaa, halis ah. Magacaabista l-thyroxine sidoo kale xaq uma laha. Cudurku laftiisa ayaa la daaweynayaa, isagoo ka xanaajiyey kororka jidhka ee heerka unugyada difaaca jirka ee loo yaqaan 'thyroglobulin'. Baadhitaanka unugyada difaaca jirka ee loo yaqaan 'thyroglobulin' waxaa loogu talagalay oo keliya ujeedada ah in la sheego ama lagu celiyo cilad-sheegashada, iyo sida loo qiimeeyo waxtarka daaweynta. Doodaha ayaa sheegaya in ay doonayaan inay lacag ku helaan bukaanka, markaa ka taxadar.