17-OH-progesterone (17-hydroxyprogesterone, 17-OGG, 17-oh-progesterone) waa hormuudka hormoonka; nooc ka mid ah "wax soo saarka wax soo saarka ah", kaas oo hormoonno kala duwan (cortisol, estradiol, testosterone) lagu sameeyay habka adag ee isbedelka dheef-shiid kiimikaadka.
Sababaha sii kordhaya 17-OH-progesterone
Sababta heerka sare ee 17-oh-progesterone ayaa inta badan laga helaa qanjidhada adrenal ama ugxan-yari. Kansarka xididada 'congenital cortex' (PDCN) waa sababta ugu badan ee kororka. Qalitaanka Adrenal wuxuu la xiriiraa la'aanta ama la'aanta 21-hydroxylase enzyme gaar ah, taas oo, la socota 17-OH-progesterone, waxay ku lug leedahay qaabaynta cortisol hormoonka. Enzyme wuxuu maqan yahay ama ku jiraa qadar yar, marka la eego horgalinta hormoonnada hormoonnada 17-OH-progesterone ayaa si firfircoon loo soo saaraa ilaa xadadka heerka caadiga ah.
Waxaa jira laba qaab oo VDKN ah: mid caadi ah iyo mid aan caadi ahayn. VDKN-da caadiga ah waxaa lagu go'aamiyaa maalmaha ugu horreeya / bilaha nolosha ilmaha marka la eego calaamadaha maqaarka dibedda ee hermaphroditism been ah. Si aad u ogaato qaabka loo yaqaan "VDKN", sida caadiga ah, waxaa suurtagal ah oo keliya dhallinyarada (ka soo horjeeda taariikhda: Hirsutism, finan, finan, caadil ah wareegga caadada) ama da'da taranka (marka haweenku la kulmaan dhibaatooyin uur qaad iyo gestation).
Intaa waxaa dheer, baaritaanka dhiigga ee lagu ogaanayo heerka 17-OH-progesterone wuxuu muujin karaa xad-dhaaf heerka:
- polycystic syndrome (PCOS);
- burooyinka soo saara kiimiko ee uur-jiifka ah ama qanjirrada adrenal;
- xanuun ama cilladda Itenko-Cushing;
- hypothalamic syndrome;
- hyperprolactinemia ;
- iyo cudurrada kale.
Qiimaha caadiga ah ee 17-OH-progesterone
Qiyaasaha hormoonada jinsiga, gaar ahaan hormoodkooda 17-OH-progesterone, waxay ku kala duwanaan karaan shaybaarro kala duwan oo lagu ogaanayo. Cilmi-baarista waa in lagu hogaamiyaa tilmaamayaasha tixraaca ee shaybaar gaar ah, waxaa badanaa lagu muujiyaa natiijooyinka falanqaynta.
Dhakhaatiirta rasmiga ah waxay u muuqdaan kuwo aaminsan in heerkul yar oo ah 17-OH-progesterone ee haween aan caafimaad qabin oo caafimaad qaba aysan u baahnayn daaweyn waana mid kala duwan. Xadka korodhkaasi waa 5 nmol / L = 150 ng / dl = 1.5 ng / l.
Dumarka uurka leh ma sameysaan tijaabo dhiig loogu talagalay 17-OH-progesterone, xilliga uurka, heerka 17-GPG wuxuu kordhiyaa, xaqiiqadani waa caadada jireed. Taasina waxay ka dhigan tahay mid aan micno lahayn in la qoro daaweyn heer sare ah oo ah 17-OH-progesterone xilliga uurka. Kaliya marka laga reebo waa xaaladaha VDKN classic.
Sida loo yareeyo 17-OH-progesterone?
Haddii, marka la eego natiijooyinka baaritaannada, heerka 17-OH-progesterone ayaa la kordhiyay, waa muhiim inaad fahamto sababaha xadgudubyada ka hor inta aan la bilaabin daaweynta. Daaweynta "indhoole", oo ay ku takhasustay tiro dheraad ah oo dhakhaatiir ah, oo ku tiirsan heerarka hore ee daweynta, ma xalliyo dhibaatada, laakiin badanaa waxay sii xumeeyaa.
Marka, sida loo yareeyo heerka 17-OH-progesterone? Iyadoo aan loo eegin sababaha keena kororka, haweeney ayaa loo qoondeeyey isticmaalka muddada-dheer ee COC - isku-ilaalinta ka hortagga afka (Jess, Yarin, Diana-3 ama kuwo kale). Sidaa darteed, haddii haweeney laguu sheego PCOS, iyadoo la shaqeynayo qanjidhada adrenal ee hal COC-daaweyn ka hor intaanay uurka la qorshayn, waa caadi ahaan.
Haddii ay sabab u tahay heerka sare ee 17-OCG waa VDKN aan caadi ahayn, baaritaan dhamaystiran oo ku takhasusay cilmi-baarista iyo cilmi-baarista dhamaystiran ee loo yaqaan 'endocrinologist' iyo 'genetics' waa lagama maarmaan,
Kordhinta 17-OH-progesterone ee inta badan kiisaska waa bacriminta halista ah. Dexamethasone, prednisolone ama glucocorticosteroids waa in la qaataa oo keliya marka la eego PDCA oo la xaqiijiyay oo keliya oo la xaqiijiyay oo keliya ayaa bixiya in uurku uusan dhicin wax ka badan 1 sano, iyo sababaha kale ee suuragalka ah ee dhalmo la'aan.